![]() The Novavax vaccine contains an adjuvant called Matrix-M. AdjuvantĪdjuvants are substances that may be added to help boost your immune response to a vaccine. They’re then extracted, purified, and placed around molecules of a compound called polysorbate 80 to form the nanoparticles. The spike proteins for the vaccine are grown in moth cells. The Novavax vaccine contains nanoparticles that are made of spike proteins. Each Novavax vaccine dose contains viral proteins, adjuvant, lipids, as well as sugar, salt, and acid stabilizers. The vaccine is already in liquid form and doesn’t need to be diluted. Another example of a protein subunit vaccine is the hepatitis B vaccine. The Novavax COVID vaccine is a protein subunit vaccine, which is similar to more traditional vaccines. These ingredients also help with stability throughout the distribution and storage process. Additionally, salt (sodium acetate) and acid (acetic acid) are included. The Moderna vaccine also contains sucrose and the acid stabilizers tromethamine and tromethamine hydrochloride. Without it, the mRNA would be destroyed, and it wouldn’t be able to enter your cells. The lipid combination is slightly different from what’s found in the Pfizer vaccine, but it has the same purpose. The mRNA molecules in the Moderna vaccine are also wrapped in an oily coating. And the amount you receive in a dose depends on your age, and if you’re receiving a primary or booster shot. The Moderna vaccine contains more mRNA than the Pfizer vaccine. And the bivalent booster vaccine is based on a combination of the original virus and the Omicron BA.4 and BA.5 subvarients. The original SARS-CoV-2 virus was used as the template for the Moderna primary series vaccine. That’s because each company made their own tiny changes to the spike protein’s genetic sequence to produce a unique immune response. And although it works the same way, the mRNA in the two vaccines aren’t identical. ![]() Like the Pfizer vaccine, the Moderna vaccine contains mRNA. The Moderna vaccine contains similar ingredients as the Pfizer vaccine, with a few differences. It’s already in a liquid form and doesn’t need to be diluted before use. The Moderna COVID-19 vaccine is also an mRNA vaccine. This change improves the vaccine’s stability and storage time when stored in the refrigerator. The new formulation has different acid stabilizers called tromethamine (“tris”) and tromethamine hydrochloride. However, the vaccine formulation was changed in December 2021. When the Pfizer vaccine was first authorized, it also contained salts to help maintain the vaccine’s acidity and stability. This ingredient helps keep the molecules in the vaccine stable, especially at different temperatures. Sugar and acid stabilizersĪll versions of the Pfizer COVID vaccine contain sugar (sucrose). And the mRNA wouldn’t be able to enter your cells and provide any benefit. Without it, your body would destroy the mRNA. This ingredient is essential for the vaccine to work. Tiny bubbles of lipid (oil) surround and protect the mRNA. These antibodies will be able to identify and fight SARS-CoV-2 more quickly if you’re exposed to it in the future. This triggers an immune response, which results in antibodies being created. Once inside your body, the mRNA instructs your cells to make the spike protein. The amount of mRNA you receive in a dose depends on your age. The bivalent (updated) vaccine is based on the original virus and the Omicron BA.4 and BA.5 subvariants. The mRNA in the Pfizer primary series vaccine is based on the original SARS-CoV-2 virus. And it’s produced in laboratory equipment, not in live cells. This mRNA holds the genetic code for the SARS-CoV-2 spike protein. The Pfizer vaccine contains copies of highly-purified messenger RNA (mRNA). Each Pfizer vaccine dose contains genetic material, lipid bubbles, as well as sugar and acid stabilizers. Certain vaccine formulations must be diluted prior to administration, while others do not. The Pfizer COVID vaccine is an mRNA vaccine. This can include genetic material, proteins, or inactive viruses, along with other components. But they contain different ingredients that help teach your immune system how to recognize it. The COVID vaccines all target the spike protein. These spike proteins enable the virus to attach to, enter, and infect our cells. It has spikes that stick out all over its surface, known as spike proteins. You may have seen pictures of SARS-CoV-2, the virus that causes COVID. So, what exactly are the COVID vaccines made of? Let’s discuss. And they don’t contain preservatives, eggs, or metals, either. None of the COVID vaccines contain a live virus, antibiotics, or latex. The Novavax vaccine, on the other hand, is similar to more traditional vaccines. The Pfizer, Moderna, and Johnson & Johnson (J&J) vaccines use vaccine technology that hasn’t been widely used before. Today, there are four COVID-19 vaccines available in the U.S.
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